Journal of Chemical and Pharmaceutical Research

ABSTRACT: Many natural products from marine sources are endowed with promising anti hypertensive activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted used in treatment of hypertension Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/recent-synthesis-of-marine-natural-products-with-antihypertensive-activity-an-overview.pdf

ABSTRACT: Several five membered aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities. This review article covers the most active thiadiazole derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory, anticancer, anticonvulsant, antidepressant, antioxidant, radioprotective and anti-leishmanial. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in terms of efficacy and safety. Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/thiadiazoles-progress-report-on-biological-activities.pdf

Journal of Chemical and Pharmaceutical Research  is an online international journal to promote all fields of Chemical Sciences like Organic Chemistry, Green Chemistry, Photochemistry, Inorganic Chemistry, Physical Chemistry, Industrial Chemistry, Biochemistry, Environmental Chemistry, Agricultural & Soil Chemistry, Analytical Chemistry, Polymer Chemistry, Macromolecular Chemistry, Petroleum Chemistry, Forensic Chemistry and Phytochemistry as well as all aspects of Chemical Engineering etc. Journal of Chemical and Pharmaceutical Research  allowing free  full-text  access and also devoted to the promotion of all fields of Pharmaceutical Sciences like Pharmaceutics, Pharmaceutical & Medicinal Chemistry, Pharmacology, Pharmacognosy, Pharmaceutical Analysis, Computational Chemistry & Molecular Modeling/Drug Design including Pharmacokinetics, Pharmacodynamics, Pharmacoinformatics, Pharmacovigilance, Chemoinformatics and Pharmacogenomics etc. Journal ...