Conventional and Greener Approach for the Synthesis of Some Novel Substituted -4-Oxothiazolidine and Their 5-Aryliden e Derivatives of 2-Methyl-benzimidazole: Antimicrobial Activities
Abstract The aim of this work was to investigate the efficiency of N 1 –(2-Benzylidene-imino-5'-methylene)-1',3',4'-thiadiazole]-2-methyl-benzimida zoles, 4(a-n); N '1 -[2 ' -{2-Substituted-Phenyl-1,3-thiazolidin-4-one}-5 ' -methylene-1',3',4'-thiadiazole]-2-methyl-benzimidazoles, (a-n)and N 1 -[2 ' -{2-substituted-phenyl-5-substituted-benzylidene-1,3-thiazolidine-4-one}-5 ' -methylene-1',3',4'-thiadiazole] - 2-methyl-benzimidazoles , 6(a-n)for the synthesis by conventional and greenar approach methods in terms of yield and reaction time along with antimicrobial activity against Bacillus subtilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteriaand Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viridefungi in vitro at 50 and 100 ppm concentrations.Some of the compounds displayed pronounced biological activity. The structures of all the new compounds were establis...