Studies on enteric coated sustained timed-release t ablets of Metronidazole
Abstract The present article deals with an oral dosage form proposed for the attainment of timed release drug delivery of metronidazole . Metronidazole containing matrix tablets coated with 3,4,5 & 6% w/v cellulose acetate phthalate in acetone were examined for applicability as timed release tablets with a predetermined lag time of 4-5 hrs. Different types of enteric coated tablets were prepared and there drug dissolution profile was studied in 0.1 N HCl (0 to 2hr) and PBS 6.8 (2-24 hr) as dissolution media at 37±0.5 ºC,100 rpm byUSP Apparatus-1(Basket assembly). The result indicated that the tablets with timed release functions could be prepared and,that the lag time were increased as the coat concentrations increased (3% to 6%w/v).