Journal of Chemical and Pharmaceutical Research

ABSTRACT: In present investigation an attempt has been made to investigate corrosion rate of mild steel, Tor steel and CRS steel in reinforced concrete. The five concrete block sites have been selected. The factor causing corrosion and conditions of the environment has been studied. Attempt has been made to consider conditions which will help to get greater protection against corrosion problem for industries as well as household articles.   Introduction :   Corrosion is the destructive attack on a metal or a metal alloy by chemical or electrochemical reaction with its environment . Metal and its alloys tend themselves to many engineering application because of their combination of lightness with strength, thermal and electrochemical conductivity, reflectivity and non toxic qualities . Iron is used in the form of stainless steel for making cutlery, hospital and food service equipment. Carbon steel is the most common, cheapest and most versatile metal used in indu...

ABSTRACT: In the present study, the wound-healing activity of some substituted hydroxytriazenes was investigated. Excision, resutured incision and dead space wound models were used to evaluate the wound-healing activity of substituted hydroxytriazenes. In excision wound model, treatment was continued till the complete healing of the wound, in incision and dead space wound models the treatment was continued for 10 days. For topical application, 5% w/w ointment of hydroxytriazenes was prepared in 2% sodium alginate and for oral administration hydroxytriazenes dissolved in DMSO, at dose 5 mg/kg were used. In excision and incision wound models, the control group of animals was left untreated and in dead space wound models the animals were treated with DMSO (1ml/kg). The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight and hydroxyproline estimation. Except the p...

ABSTRACT: A rapid, sensitive and specific RP-HPLC [1-5] method involving UV detection was developed and validated for determination and quantification of Lamivudine and Zidovudine. Chromatography was carried out on a pre-packed AltimaC18 5µ (150*4.6mm) column using filtered and degassed mixture of Ammonium acetate buffer:Methanol (80:20) as mobile phase at a flow rate of 1.0ml/min and effluent was monitored at 270nm. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of quantification and limit of detection. The assay was linear over the concentration range of Lamivudine and Zidovudine was 37.5mcg-112.5mcg/ml and 75mcg to 225mcg/ml respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analyzed test solution and was found to be 98.50%-99.9% and 98.30%- 100.10% within precision RSD of 0.71 and 0.82 for Lamivudine and Zidovudine respectively. The system suitability...