Journal of Chemical and Pharmaceutical Research

ABSTRACT: Allium cepa is highly valued for its therapeutic properties. It has been used as a food remedy from time immemorial.Research shows that onions may help guard against many chronic diseases. That's probably because onions contain generous amounts of the flavonoid quercetin. Studies have shown that quercetin protects against cataracts, cardiovascular disease, and cancer. In addition, onions contain a variety of other naturally occurring chemicals known as organosulfur com-pounds that have been linked to lowering blood pressure and cholesterol levels.Although rarely used specifically as a medicinal herb, the onion has a wide range of beneficial actions on the body and when eaten (especially raw) on a regular basis will promote the general health of the body. The bulb is anthelmintic, anti-inflammatory, antiseptic, antispasmodic, carminative, diuretic, expectorant, febrifuge, hypoglycaemic, hypotensive, lithontripic, stomachic and tonic. When used regularly in the diet ...

ABSTRACT: The Raman Effect occurs when light impinges upon a molecule and interacts with the electron cloud and the bonds of that molecule. Raman spectroscopy is commonly used in chemistry, since vibrational information is specific to the chemical bonds and symmetry of molecules. It therefore provides a fingerprint by which the molecule can be identified.A new spectroscopy technique to uncover the precise sequence of atomic movements and structural changes that occur during complex chemical transformations. GFP involves a classic intermolecular proton transfer reaction to produce its fluorescent form. This happens on an ultra fast timescale - from 10 femtoseconds to 10 picoseconds. To perform structural measurements and determine the mechanism and pathway of any reaction occurring in this time range by using femtosecond stimulated Raman spectroscopy (FSRS). A great deal was known about the kinetics of the proton transfer reaction but little was known about the actual complexity ...

ABSTRACT: Many natural products from marine sources are endowed with promising anti hypertensive activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted used in treatment of hypertension Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/recent-synthesis-of-marine-natural-products-with-antihypertensive-activity-an-overview.pdf

ABSTRACT : Melanin is a natural pigment with great development potential as a healthful food colorant. In this paper, melanin from black tea leaves was extraction and purification and its physicochemical properties and stability were investigated. The experimental results showed that melanin was insoluble in both water and common organic solvents. It dissolved only in alkali aqueous solution and precipitated acidic aqueous solution (pH < 3). Melanin was gradually oxidative bleached by oxidant and was stable to reducer. These physicochemical properties were very similar to those of the melanin reported in the previous studies. Melanin had good resistance to light decomposition and heating treatment. Therefore, melanin from black tea leaves could be further used as a natural food colorant. Further details @ http://www.jocpr.com/ For more details @  http://www.jocpr.com/articles/physicochemical-properties-and-stability-of-melanin-from-black-tea-leaves.pdf

ABSTRACT : The occurrence, metabolism and toxicity of medicinally active drugs in the aquatic environment has been recognized as one of the emerging issues in environmental chemistry. In some investigations carried out in various countries like Spain, Greece, England, Canada, Italy, Austria, Brazil, Croatia, and the U.S., more than 100 compounds, pharmaceuticals and several drug metabolites, have been detected in the aquatic environment. Several drugs from various prescription classes have been found at concentrations up to the µg/ l-level in influent and effluent samples and also in several surface waters located downstream from municipal sewage treatment plants. The present review in designed to collect the information about the various drug in aquatic environment and their analysis with respect to antipsychotics, anticancer, antibiotics and other commonly used drugs to provide the information for safe use of drugs and to avoid the toxicity of these drug to the environmental l...

ABSTRACT : The separate situation of research has area coverage or target coverage in wireless sensor networks. Based on directional sensing model ， the algorithm used the virtual potential field to make the sensor nodes shift positions and change directions automatically in monitoring area. Coverage on multiple targets is mainly in the quality of coverage and network service system. Coverage for multi-objective design is a multi-objective genetic algorithm to solve multi-objective optimization problem. Thinning algorithm can be found in the border region of the demand point for sparse areas which needs to make the search more uniform distribution of the solution. The operator introduces the compound of crossing two operators and a uniform mixing of the single point to make an analog binary search function be weak cross defects, and gives proof of the convergence of the algorithm by simulation to verify the effectiveness of the algorithm. Further details @ http://www.jocpr....

ABSTRACT : Allergic rhinitis (AR) is an IgE-mediated disease that can impact the quality of life and work of affected individuals. Antihistamines were introduced more than 50 years ago for the treatment of AR. They can be classified into three groups. First-generation antihistamines such as promethazine and ketotifen are clinically effective, but they have a considerably limited use by their sedative and anticholinergic effects. Second-generation antihistamines such as cetirizine, loratadine1 and mizolastine have significantly fewer sedative and anticholinergic effects than first-generation. New generation antihistamines include fexofenadine, levocetirizine, desloratadine2 and rupatadine. While many of these agents were largely devoid of CNS (central nervous system) side effects, their tendency for drug-drug interactions (e.g., terfenadine and astemizole) resulted in an increase incidence of cardiotoxicity. Furthermore, some of the second-generation H1 antagonists exhibited weak...

ABSTRACT : Gives the design and analyses the procedure of the method of validity guaranteeing of ForCES (forwarding and control element separation) LFB (logical function block) topology. To improve efficiency of the method, patternmatching technology is also introduced. According to the character of LFB topology and comparing with various pattern-matching, we employ the multi-pattern matching and related algorithm for our implementation. Further details @ http://www.jocpr.com/ For more details @  http://www.jocpr.com/articles/the-research-and-implementation-of-a-method-of-validity-guaranteeing-in-forces-system.pdf

ABSTRACT : In order to precisely control move of underwater robots, the fuzzy PID dual-mode controller based on fuzzy rules switching is invented, combining the conventional fuzzy controller and the more precise PID controller. Fuzzy rules are switched on the basis of different moves of underwater robots. The new controller has been conducted simulation and field experiments on underwater synthetic explored robots. The experiments show that, with pragmatic design and good dynamic performance like traditional controllers, the new controller improves precision while reduces overshoot. It also has good robustness when dealing with uncertainty of the model and external disturbances. On the whole, it has higher pragmatic value. Further details @ http://www.jocpr.com/ For more details @  http://www.jocpr.com/articles/design-of-fuzzy-rules-switchingbased-fuzzy-pid-controller-of-underwater-robots.pdf

ABSTRACT : Isatin thiosemicarbazone and its metal complexes have been prepared and structurally characterized by elemental analyses and FT-IR, electronic and 1H-NMR, 13C-NMR spectra. The theoretical wavenumbers, IR intensities, 1HNMR, 13C-NMR spectroscopy, UV absorption spectra and and molecular parameters were calculated by the B3LYP method. Frontier molecular orbital energies, bond length and charges on the atoms of I4NPTH2 and I2-4CPTH2 were studied by the B3LYP method using 6-31G (d,p), 6-311G (d,p), 6-311++G (d,p), 6-311++G (2d,2p)basis sets in gas and DMSO phases. Results showed that compounds 8, 10 and 5 are potent inhibitors of in vitro protein glycation with IC50 value of 111.30 ± 1.96, 113.00 ± 0.9 and 161.51 ± 0.47 µM, respectively While compounds 1- 4 were found to be inactive. Further details @ http://www.jocpr.com/ For more details @  http://www.jocpr.com/articles/synthesis-biological-activity-and-theoretical-study-of-some-isatin-and-theirmetal-complex...

ABSTRACT : In this study, marine eukaryotic microbial community was analyzed in the context of its complexity and dynamic process in the early stage of biofouling. Samples were collected from five different surfaces: the control group (coating CG), 0.2% Silicium (Coating A), 2% Carbon nanopowder (Coating B), 0.2% Graphite (Coating C) and 2% Silicium plus 2% Carbon nanopowder (Coating F). These coatings were sea-tested for 11 months for their anti-biofouling performance. Coating A and B don’t have anti-biofouling ability just like coating CG, while coating C and F have excellent anti-biofouling capacity. Single stranded conformation polymorphisms (SSCP) was employed to analyze diversity level and dynamic changes of marine fouling eukaryotic communities adhering to different coatings during different sampling time (day 2, 4, 6, 9 and 14). The results indicated that composition, distribution and diversity level of marine fouling eukaryotic microbial community presented obviously di...

ABSTRACT : The effect of antimony (Sb) addition in SeIn glassy system is theoretically studied, and important physical properties, such as average coordination number, lone pair electrons, fragility parameter, heat of atomization, mean bond energy and optical band gap are evaluated in addition to thermal stability. The values of average coordination number and heat of atomization were found to increase with increasing Sb content, while the other properties were in decrease. By adding more Sb atoms, the glassy system becomes less stable thermally. According to the number of zero-frequency mode per atom, which was in decrease, the Phillips’-Thorpe threshold cannot be realized for the considered glassy system. Further details @ http://www.jocpr.com/ For more details @  http://www.jocpr.com/articles/theoretical-study-of-sbdoped-se90in10-glassy-system.pdf

ABSTRACT : Regional anesthetic techniques have become more popular in the recent years with the primary advantage being lowering of general anesthetic requirement and provision of good postoperative pain relief. Single shot caudal epidural anesthesia is the most commonly performed regional technique in pediatric anesthesia. The objective of this study is to compare the efficacy of postoperative analgesia, comparison of pain scores and duration of analgesia between two different doses of inj.fentanyl along with bupivacaine through caudal route for pediatric patients undergoing elective infraumbilical surgery. Our study was done in 50children randomly divided into two groups of 25 each. Group I received 1ml/kg of 0.125%bupivacaine plus fentanyl 0.5µg/kg and group II received 1ml/kg of 0.125%bupivacaine plus fentanyl1µg/kg for caudal block post induction. Postoperatively patients were assessed for efficacy of analgesia with comparison of pain scores (MOPS) and duration of analgesia...

ABSTRACT : Many studies show that rural left-behind children and “un-left-children” have significant differences such as psychology, behaviors and learning. In some rural areas, left-behind children have high dropout rate. The article surveyed rural left-children present situation of alienation in Henan province and found out the alienation of left-behind children is stronger than un-left-behind children, mainly reflected in normlessness, powerlessness and isolation. According to the situation, selecting subject for group counsel and the effect is significant. The result shows group counseling is a successful way and favored by students. It is worth promoting. Finally, put forward suggestions. Further details @ http://www.jocpr.com/ For more details to visit @  http://www.jocpr.com/articles/rural-leftbehind-children-present-situation-of-alienation-from-school-and-intervention-studyseeking-to-improve-the-alien.pdf

ABSTRACT : With the development of modern technologies, it becomes increasingly important to find a way to effectively utilize and management the intelligent library. For this reason, the intelligent library management system is designed and implemented based on RFID / GRPS. The final experimental results suggest that the proposed approach is feasible and correct. Further details @ http://www.jocpr.com/ For more details to visit @  http://www.jocpr.com/articles/the-design-and-implementation-of-intelligent-library-management-system-based-on-rfidgrps.pdf

ABSTRACT : Little universal method is monitored p-chlorophenols compounds in environmental media. In the paper, analytic method of p-chlorophenols compound by high performance liquid chromatography (HPLC) was optimized. The result were that the mobile phase was 0.5% phosphoric acid and acetonitrile, and flow rate was 1.5mL/min. The column temperature of HPLC was 30 ℃ , and the injection volume was 10μL, detection wavelength was 218nm. In monitoring process, the gradient elution mode determination of pentachlorophenol was used. In this condition, the pentachlorophenol, o-chlorophenol, m-chlorophenol and phenol could be seperated very well, the standard cures were Y=68.523x+360.08, Y=18.392x+17.575, Y=20.09x+16.319, and Y=26.379x+17.061, respectively. And the relative standard deviation (RSD) was 0.83%, 1.04%, 0.91%, 0.40%, respectively. The average recovery of the added index were from 89.17~100.58%.At last, sample of pentachlorophenol wastewater after biodegradation was monitore...

ABSTRACT : Dringo plant (Acorus calamus L.) is a medicinal plant with the main chemical components (major compound) is asaron (β-asarone) are commonly found in a rhizome, but did not rule these compounds are also present in other parts including leaves. β-asarone have high activity against Microsporum gypseum as antimicrobial, Trichopyton rubrum, and Penicillum marneffei and have anti-carcinogenic effects. This study aimed to determine the contents of β-asarone most of the leaves and rhizomes of plants dringo (A. calamus) by TLC-densitometry method. The leaves and rhizomes of each extracted by maceration method using n-hexane solvent. TLC performed on a standard profile and the sample was eluted with the eluent n-hexane: ethyl acetate (8: 2), then the TLC profiles scanned by TLCdensitometry at a wavelength of 313 nm maximum. The results showed levels of β-asaron on plant rhizomes dringo (A. calamus) leaves more than a ratio of 1: 0.58. β-asarone contained in the rhizome as 2743....

ABSTRACT : The fault parameters of ball mill was unnoticed among large amount of data, According to the phenomenon, it put forward a fault diagnosis method of rough set to optimize neural network, and by using width algorithm, so that the fault sample set of ball mill had been processed with the discrete way. Firstly, it builded a diagnosis model of rough set-neural network, the diagnosis model had practicability and superiority compared with single network model. For more details to visit @ http://www.jocpr.com/ Further details @     http://www.jocpr.com/articles/application-research-on-rough-set-neural-network-in-the-fault-diagnosis-system-of-ball-mill.pdf

ABSTRACT : Shot put as one of important composition items in athletics competition, throwing distance is main concerned problems by coaches and athletes. From general knowledge of throwing, it is known that there are mainly three factors affect throwing distance as initial speed when shot out of hands (m/s), throwing angle (angle) and throwing height (meter). By far, utilize physics kinematics knowledge researching shot put movement phenomenon is more, and less considering about throwing height influences when researching. The research on the basis of physics correlation knowledge, regard thrown shot as particle making projectile motion, and establish shot throwing distance mathematical model. Consider affect shot putter throwing main factors as shot throwing angle, shot initial speed and shot throwing height. According to model, it analyzes when throwing speed and throwing height are fixed, solve optimal throwing angle, let throwing distance be the maximum, it provides a basis ...

ABSTRACT : Viscum species have been widely used in herbal medicine, such as nervine, hypertensive, cardiac depressant, vasodilator, slowing and steadying of excessive heart rate, relaxant and diuretic. The genus Viscum L. (Loranthaceae) comprises semi-parasitic plants which grow on various host tree and shrubs In Turkey, Viscum L. is represented by one species (Viscum album L.) and three subspecies; namely ssp. album, ssp. abietis (Wiesb.) Abromeit and ssp. austriacum (Wiesb.) Vollmann and is known with a common name as ‘Ökse Otu’. In the present study, the effect of Viscum album ssp. album L. extract on partially hepatectomized rats was investigated with biochemical assay. The extracts of the plant at the concentrations of 1 and 1.5 ml/100 g body weight/day were administered orally to the two experimental groups including partially hepatectomized rats for 14 days. At the end of the experimental period, animals were sacrificed, blood was collected for the assessment of serum lev...