Journal of Chemical and Pharmaceutical Research

ABSTRACT The chloroform, ethanol and water extracts of pulve rised dried leaves of Cyphostemma glaucophilla were used in this study. Three sets of inbred Wistar albino rats of either sex aged 7-9months and weighing 100-150g were fed on Top feed rat diet and allowed freeaccess to water before and during the experiment. For each extract, five groups A, B, C, D and E of five animals each were respectively served daily doses of saline [0.85% Nacl,5ml/kg],0.5,1.0,1.5 and 2.0mg/kg respectively extract for 14days using stomach tubes. Twenty four hours after the last administration, the animals were sacrificed by ether anaesthesia. Blood samples were drawn into heparinised tubes by cardiac puncture and centrifuged at 5000xg for 10minutes.The supernatant was used as plasma.

ABSTRACT The effects of aqueous extract of pulverised dried leaves of Cyphostemmaglaucophilla was investigated in two sets of experiment. Thirty Rattus norvegicusof either sex, aged 7-9months and weighing 100-130g were randomly assigned to five experimental group, A, B, C, D, and E of six animals each and were served single intraperitoneal daily doses of salinetetracycline was not significant [0.06±0.02mg/dL]. However, inhibition with Chloramphenicol and streptomycin was significant[4.60±0.02, 4.50±0.