Journal of Chemical and Pharmaceutical Research

ABSTRACT Benzoxazine and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review coversupdated information on the most active benzoxazine derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, antimycobacterial, anti-diabetic, antihypolipidaemic, and antidepressant. It can act as an important tool for chemists to develop newer benzoxazine derivatives that may prove to be better agents in terms of efficacy and safety.

Abstract  Indanone acetic acid is a non-heterocyclic fused ring of benzene with cyclopentananone moiety with acetic acid side chain in 1-position. This specific moiety has been synthesised and condensed with various substituents like PABA, piperidine, morpholine, benzimidazole, piperazine, pyrazolone and hydrazine to get the desired product for animicrobial screening by zone of inhibition study and MIC values with respect to some gram positive and gram negative microbes and fungal strains with reference standardantibiotics. The satisfactory result has beenfound in the antimicrobial and antifungal screening.