Journal of Chemical and Pharmaceutical Research

ABSTRACT: To study describe the actions of antipsychotics or neuroleptics on the behavioral effects elicited by ketamine on open-field, rota rod and tail suspension tests in mice. A series of novel analogs of 2-[3-{4-(3-chlorophenyl)-1-piperazinyl} propyl]-1,2,4-triazolo [4,3-a] pyridine-3- (2H)-one hydrochloride, a potential psychoactive drug of the piperazine and triazolopyridine chemical classes that has antidepressant, anxiolytic, and hypnotic properties were synthesized. Male swiss albino mice (25–30g) were used for the study and compounds were administered alone (0.1 or 0.2 mg/kg) or thirty minutes before ketamine (10 mg/Kg, ip). ketamine increased (63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by ketmine. Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/studies-of-antipsychotic-drugs-as-pote...

ABSTRACT: Metal chelates of biologically important Schiff bases namely 4-methyl-2-{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol(MEMIIMP) and 5-methoxy-2--{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol(MMIIMP) with Cu(II), Ni(II), Co(II), Zn(II) and VO(IV) have been synthesized. The metal chelates have been characterized by elemental analysis molar conductivity data TG, DTA, spectral (IR, 1H-NMR, Mass, ESR and electronic) and magnetic moments. The dissociation constants of Schiff bases and stability constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes have been determined potentiometrically in aquo organic medium at 30±1oC and at 0.1 M KNO3 ionic strength. Antimicrobial activities of Schiff bases and their complexes were screened against bacteria & fungi are discussed. Introduction :   Studies on a new kind of chemotherapeutic Schiff bases are now attracting the attention of biochemists. Schiff base complexes derived from 4-hydroxy salicylal...

ABSTRACT: Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. In the recent years, focus on the development of controlled release drug delivery systems has increased. The basic rationale of controlled release drug delivery system optimises the biopharmaceutical, pharmacokinetic, and pharmacodynamic properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure or control of the condition is achieved, in the shortest possible time by using smallest quantity of drug administered by the most suitable route. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilisation of the drug, increased safety margin of potent drug, reduction in healthca...

ABSTRACT: Nimesulide is a second generation non–steroidal anti–inflammatory agent, which is widely used in the long term therapy of rheumatoid arthritis, in alleviating pain and inflammation. But its short half-life (only 3–4hrs.), so its causes more fluctuation. After oral administration Nimesulide causes to produces heart burn, nausea, loose motions, pruritus, etc. The present study based on the preparation of bioadhesive topical gel of Nimesulide, so as to avoid all gastric side effects. For the preparation of bioadhesive topical gel natural polymer aegel marmelos (plant Bale) was used. Bioadhesive polymers are the agents which increases the contact between the formulation and biological membrane, so as to avoid the fluctuation of formulation and behave as a sustained release formulation. In the present study, prepared bioadhesive topical gel was evaluated with the help of different parameters like drug content, spreadability, extrudability, swelling index study, in–vitro dru...

ABSTRACT: A differential pulse polarographic (DPP) method for the determination of Flumetralin is described based on the reduction of a nitro group at a dropping mercury electrode (DME) in Briton-Robinson buffers of pH 2.0 to 12.0 using 25% acetone-water mixture as a solvent. Also a cyclic voltammetric (CV) technique has been used to study the behaviour of Flumetralin at a hanging mercury drop electrode (HMDE). The DPP method described here has been applied to the analysis of Flumetralin in formulations, grains, soils and spiked water samples. Both standard addtion and calibration methods were used for the analytical measurements. The lower detection limit was found to be 1.87x10-8 M. Introduction : Pesticides containing nitro substituents are extensively used in agriculture throughout the world. Flumetralin is one of the dinitroaniline pesticide families and is an economically important class of agricultural compound used to prevent the growth of grasses and weeds in cu...

ABSTRACT: Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a bone marrow disease, there are problems with the stem cells or how they develop. Leukemia is a cancer in which the bone marrow produces abnormal white blood cells. With aplastic anemia, the bone marrow doesn't make red blood cells. Other diseases, such as lymphoma, can spread into the bone marrow and affect the production of blood cells. Other causes of bone marrow disorders include your genetic makeup and environmental factors. The cell compression caused by an overgrowth of the supporting fibrous tissue network, resulting in abnormally shaped cells and decreased numbers of cells. One cell line that becomes predominant because the c...

ABSTRACT: The Raman Effect occurs when light impinges upon a molecule and interacts with the electron cloud and the bonds of that molecule. Raman spectroscopy is commonly used in chemistry, since vibrational information is specific to the chemical bonds and symmetry of molecules. It therefore provides a fingerprint by which the molecule can be identified.A new spectroscopy technique to uncover the precise sequence of atomic movements and structural changes that occur during complex chemical transformations. GFP involves a classic intermolecular proton transfer reaction to produce its fluorescent form. This happens on an ultra fast timescale - from 10 femtoseconds to 10 picoseconds. To perform structural measurements and determine the mechanism and pathway of any reaction occurring in this time range by using femtosecond stimulated Raman spectroscopy (FSRS). A great deal was known about the kinetics of the proton transfer reaction but little was known about the actual complexity ...

ABSTRACT: Medicinal plants are finding use as pharmaceuticals, nutraceuticals, cosmetics and food supplements. Even as traditional source of medicines and they continue to play pivotal rule. Ethanolic extract of three medicinal plants viz., Acalypha indica, Ricinus communis and Euphorbia hirta were evaluated for there therapeutic potential as antimicrobial agent against six standard organisms 3 bacteria (Klebsiela pneumoniae, Salmonella typhi, Pseudomonas aeruginosa) and 3 fungi (Aspergillus flavus, Fusarium oxysporium, Penicillium chrysogenum) by using Filter Paper Disc Method. Antimicrobial efficacy of callus cultures of E. hirta with inhibition zone of 16 mm was found to highest against F. oxysporium (Fungus) and in A. indica with inhibition zone of 27 mm was found to maximum against K. pneumoniae (Bacteria). Contrary, in in vivo analysis of antimicrobial efficacy of A. indica with inhibition zone of 15 mm were found to highest against P. chrysogenum (Fungus) and E. hirta wit...

ABSTRACT: Anti-inflammatory drug ketoprofen was encapsulated in niosome for topical application. Ketoprofen niosome were prepared by thin film hydration method technique using surfactant, cholesterol, dicetyl phosphate & drug mixture in different weight ratios. The prepared niosomes were characterized by various physicochemical parameters & evaluation of release studies of entrapped ketoprofen in niosomes were carried out by UV Visible spectrophotometric method. Introduction :   Niosomes are surfactant vesicles which are used to entrap several pharmaceutical drugs to enhance their sustainability . The present research is attempt towards development of topical application of ketoprofen niosomes. so that drug will reach to target site with enhance sustainability & stability. The novelty of research work is to provide effective and maximize drug concentrations and therapeutic value. Materials and Methods : Sorbitan Esters-20, 40, 60 & 80 & Ch...

ABSTRACT: Aloe vera contains numerous vitamins and minerals, enzymes, amino acids, natural sugars and agents which may be anti-inflammatory and anti-microbial. The combination and balance of the plant's ingredients are what purportedly gives it its healing properties. The part of the Aloe vera which is used are the leaves. The Aloe is an Emollient, Purgative and Vulnerary. It is also used for its antibacterial, anesthetic and antiseptic properties, and is good to use as a tool for restoration of tissue. It is most commonly used on burns and minor cuts, especially good for sunburns, although it is being used for the treatment of skin cancer. Aloe is very useful on rashes caused by Poison Ivy, and it may help to draw out infection. It may help with Vaginal Yeast Infections, although this is not solid at this time. Aloe be made into a warm tea, made from the juice as a wash for eyes. The washing of eyes with Aloe may protect the eyes from ultraviolet rays from the sun. It can b...

ABSTRACT: N 4 [(E)-1-(2-hydroxyphenyl)methylidene] isonicotinohydrazide abbreviated as NHPM were synthesized and characterized. Ti(IV) and Cu(II) metal complexes of this ligand prepared by reaction of fluoride salt of Ti(IV) and acetate salt of Cu(II) with NHPM in dry acetonitrle. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR and UV–Visible spectroscopy. These new complexes showed excellent antitumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells. Introduction:   Presently, there is a growing interest in the coordination chemistry of structurally modified bio-ligands. Transition metal complexes with potential biological activity are the focus of extensive investigations . Metal complexes of biologically important ligands are sometimes more effective than the free ligands . Metal based drugs have been used in medicine for...

Journal of Chemical and Pharmaceutical Research  is an online international journal to promote all fields of Chemical Sciences like Organic Chemistry, Green Chemistry, Photochemistry, Inorganic Chemistry, Physical Chemistry, Industrial Chemistry, Biochemistry, Environmental Chemistry, Agricultural & Soil Chemistry, Analytical Chemistry, Polymer Chemistry, Macromolecular Chemistry, Petroleum Chemistry, Forensic Chemistry and Phytochemistry as well as all aspects of Chemical Engineering etc. Journal of Chemical and Pharmaceutical Research  allowing free  full-text  access and also devoted to the promotion of all fields of Pharmaceutical Sciences like Pharmaceutics, Pharmaceutical & Medicinal Chemistry, Pharmacology, Pharmacognosy, Pharmaceutical Analysis, Computational Chemistry & Molecular Modeling/Drug Design including Pharmacokinetics, Pharmacodynamics, Pharmacoinformatics, Pharmacovigilance, Chemoinformatics and Pharmacogenomics etc. Journal ...