Studies of Antipsychotic drugs as potential schizophrenia agents


ABSTRACT:

To study describe the actions of antipsychotics or neuroleptics on the behavioral effects elicited by ketamine on open-field, rota rod and tail suspension tests in mice. A series of novel analogs of 2-[3-{4-(3-chlorophenyl)-1-piperazinyl} propyl]-1,2,4-triazolo [4,3-a] pyridine-3- (2H)-one hydrochloride, a potential psychoactive drug of the piperazine and triazolopyridine chemical classes that has antidepressant, anxiolytic, and hypnotic properties were synthesized. Male swiss albino mice (25–30g) were used for the study and compounds were administered alone (0.1 or 0.2 mg/kg) or thirty minutes before ketamine (10 mg/Kg, ip). ketamine increased (63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by ketmine.

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