Synthesis and biological evaluation of(4-substituted benzylidene)-3-methyl-1-(substituted phenyl sulfonyl and substituted benzoyl)-1H-pyrazol-5(4H)-one as anti-inflammatory agent
Abstract The Synthesis of 5-methyl -2,4-dihydro-3H-pyrazole-3-one is prepared by the cyclisation reaction between etylaceto acetate and hydrazine hyd rate in absolutealcohol.(compound 1). 5-methyl -2,4-dihydro-3H-pyrazole-3 one react with substituted benzaldehyde to prepare4-(4-substitutedbenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (compound 2) . 4-(4-substituted benzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and substituted benzoyl chloride and substituted benzene sulfonyl chloride and add Triethylamine1 to2 drops and stirring for 4 hr and evaporate Trietylamine on water bath and product of (4-Substituted benzylidene)-3-methyl-1-(Substituted Phenyl Sulfonyl and substituted benzoyl)-1H-pyrazol-5(4H)-one(compound 3 and 4)obtained For more info: http://www.jocpr.com/articles/synthesis-and-biological-evaluation-of-4substituted-benzylidene3methyl1substituted-phenyl-sulfonyl-and-substituted-benzo.pdf