Formulation Development and evaluation of Fast Diss olving Tablets of Carvedilol
Abstract Carvedilol is a poorly water soluble oral antihypertensive agent, with problems of variable bioavailability and bioequivalence related to its p oor water solubility. Carvedilol is a nonselective beta adrenergic blocking agent with alpha-1 blocking activity and is indicated for the treatment of hypertension and mild to moderate heart failure of ischematic or cardiomyopathic origin In the present work solubility was enhanced by using β - cyclodextrin as a complexing agent. Sweeteners and flavors were used to enhance the organoleptic properties of tablet. Solubility studies were performed to investigate the drug carrier interaction. I.R. and D.S.C studies carried out to investigate any interaction and stability of formulation. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wettingtime, in-vitro disintegration time, drug content and in vitro drug release. Fo...