Journal of Chemical and Pharmaceutical Research

ABSTRACT Earthworm plays a major role in the proper functioning of the soil ecosystem. It acts as scavenger and helps in recycling of dead and decayed plant material by feeding on them. Earthworm increases the soil fertility and is often referred to as a farmer’s friend. Earthworms have been used in medicine for various remedies. In the present investigation, various solvent extracts of an earthworm, Eudrilus eugeniae were prepared and antimicrobial activity of these extracts were determined by well diffusion method.

ABSTRACT The in vitro antimicrobial activity of Cassia didymobotrya and Phlogacanthus thyrsiflorus leaf extracts were studied against selected bacteria andfungi following Agar disc diffusion method. Leaves were extracted using distilled water, methanol and ethyl acetate. Three different concentrations were applied to the disc (100μ g, 250μ g and 500μ g/disc) for each extracts. While the aqueous extracts of the selected plants leaves showed mild to moderately effective, the methanol and ethyl acetate extracts were more efficient compared to the aqueous extract.

ABSTRACT In the present investigation, a series of uracil formazans (5a-r) were synthesized by condensation of schiff base (4a-c) and diazonium salt of various substituted aromaticamines. The intermediate schiff base (4a-c) was itself synthesized by condensation of (6-hydrazino-3-methyl uracil) with various aromatic aldehydes (3a-c). The structures of the compounds have been confirmed by elemental analysis and spectral analysis. Newly synthesized compounds were screened for their antimicrobial activities.

Abstract Synthesis of 4-substituted phenyl (11H,16H-5,6-dioxa-11a,15b-diaza-5a λ 5 -phosphabenzo[b] naphtha-[2, 3-l] fluoren-5-yl) ether (4a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with various phenols in dry tetrahydrofuran in the presence of TEA underreflux condition. These compounds were characterized by IR, 1 H, 13 C and 31 P NMR and were found to exhibit potent antimicrobial activity.

Abstract  The aim of this work was to investigate the efficiency of N 1 –(2-Benzylidene-imino-5'-methylene)-1',3',4'-thiadiazole]-2-methyl-benzimida zoles, 4(a-n); N '1 -[2 ' -{2-Substituted-Phenyl-1,3-thiazolidin-4-one}-5 ' -methylene-1',3',4'-thiadiazole]-2-methyl-benzimidazoles, (a-n)and N 1 -[2 ' -{2-substituted-phenyl-5-substituted-benzylidene-1,3-thiazolidine-4-one}-5 ' -methylene-1',3',4'-thiadiazole] - 2-methyl-benzimidazoles , 6(a-n)for the synthesis by conventional and greenar approach methods in terms of yield and reaction time along with antimicrobial activity against Bacillus subtilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteriaand Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viridefungi in vitro at 50 and 100 ppm concentrations.Some of the compounds displayed pronounced biological activity. The structures of all the new compounds were establis...