Selective Extraction of 7-aminodeacetoxycephalospor anic acid and Cephalexin antibiotics with Aliquat-336
ABSTRACT The reactive extraction of7-ADCA (aminodeacetoxycephalosporanic acid) and Cephalexin with Aliquat-336 (tricaprylmethyl ammonium chloride) dissolved in n-butyl acetate as solvent has been studied over a pH range of 5 to 8. The effect of such parameters as Aliquat-336 concentration, pH and 7-ADCA and Cephalexin concentrations on distribution coefficient in the reactive extraction system has been evaluated. It was found that distribution coefficient (K d ) increases with increases of the aqueous phase pH implying that the anionic forms of the dissociated 7-ADCA and cephalexin are amendable forreactive extraction.