Journal of Chemical and Pharmaceutical Research

Abstract Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, anti tumor, antioxidant and anti-HIV activity. Imidazoles and triazoles have also been exploited for antimicrobial and antioxidant activities. In the present investigation the quinazolinone moiety has been clubbed with imidazole and triazole heterocyclic moiety to obtain the title compounds. All the synthesized compounds have been screened for their antibacterial activity against S.aureus (NCIM 2079), B.subtilis (NCIM 2697), E.coli (NCIM 2065)and K.pneumonia(NCIM 5082) and invitroantioxidant activity by 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method. Interestingly the compounds containing thiol group showed pronounced antioxidant activity than other derivatives of the series.

Abstract The use of quantitative structure–activity relationships, since its advent, has become increasingly helpful in understanding many aspects of biochemical interactions in drug research . This approach was utilized to explain the relationship of structure with biological activity of antibacterial. For the development of new fungicides against, the quantitative structural–activity relationship (QSAR) analyses for fungicidal activities of Pyrroledione Derivatives were carried out using multiple linear regression (MLR) Quantitative structure–activity relationship (QSAR) analysis was performed on a series of 3-Bromo-4-(1-H-3-Indolyl)-2, 5-Dihydro-1H-2, 5- Pyrroledione Derivatives.QSAR investigations were based on Hansch's extra thermodynamic multi-parameter approach. QSAR investigations reveal that steric and electrostatic interactions are primarily responsible for enzyme–ligand interaction . These studies produced good predictive models and give statistically significant ...

Abstract  The use of quantitative structure–activity relationships, since its advent, has become increasingly helpful in understanding many aspects of biochemical interactions in drug research. This approach was utilized to explain the relationship of structure with biological activity of antibacterial. For the development of new fungicides against, the quantitative structural–activity relationship (QSAR) analyses for fungicidal activities of Pyrroledione   Derivatives were carried out using multiple linear regression (MLR) Quantitative structure–activity relationship (QSAR) analysis was performed on a series of 3-Bromo-4-(1-H-3-Indolyl)-2, 5-Dihydro-1H-2, 5- Pyrroledione Derivatives.

Abstract  Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, antitumor, antioxidant and anti-HIV activity. Schiff bases have also been exploited extensively for antimicrobial and antioxidant activities. In the present investigation various quinazolinone amines have been clubbed with five membered heterocyclic aldehydes to obtain the title compounds. All the synthesized compounds have been screened for their antibacterial activity against S.aureus, B.subtilis, E.coli and K.pneumoniaand invitroantioxidant activity by 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method.

Abstract  A new series of Anti bacterial and Anti fungal agents with 2-(5-amino-1, 3, 4-thiadiazol-2-yl) phenol as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by IR and 1 HNMR spectral methods. The compounds were screened for antibacterial activity against pathogenic microbes Bacillus subtitles, Staphylococcus aureus, E.coli, in comparison with the reference drug Ampicillin, Ciprofloxacin and Doxycycline and anti fungal activity against Candida Albanians and comparable to that of Fluconazole as a reference drug and in this investigation the significant level of activity was illustrated For  more info: http://www.jocpr.com/articles/synthesis-and-study-of-antibacterial-and-antifungal-activity-of-novel-25substituted-methylamino134thiadiazol2ylphenols.pdf