Journal of Chemical and Pharmaceutical Research

Abstract Simple, rapid, sensitive and accurate UV- Spectrophotometric methods have been developed for estimation of Voglibose in pharmaceutical formulation. Since Voglibose only absorbs UV in the low wavelength region, it cannot be detected with high sensitivity. So special detection methods are necessary for analysis of Voglibose. Voglibose shown effective results for various analytical instruments only in the combination of Taurine and Sodium period ate. Drug solution was derivatized using Taurine and Sodium period ate in water and methanol. Drug exhibited distinct λ max in methanol at 282nm. Linearity was observed in the concentration range 10-80 μ g/ml. (r 2 = 0.997). Amounts of drug estimated from tablet formulation were in good agreement with label claim. The method was validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of voglibose in bulk and tablet dosage forms.

Abstract  A simple sensitive spectrophotometric method in UV region has been developed for the determination of Ceftazidime in bulk dosage form. The solution of ceftazidime in 0.1N HCl shows maximum absorbance at 261nm, beer’s law was obeyed in the concentration range of 2-10 μ g ml -1 . The absorbance was found to increase linearly with increasing concentration of ceftazidime, which is corroborated by the calculated correlation coefficient value of 0.9981. The slope and intercept of the equation of the regression line are 0.0465 and 0.0007 respectively. The analysis were validated statistically and its recovery studies result of percentage shows that the method was not affected by the presence of excepients which proves suitability of the developed method for the routine estimation of ceftazidime bulk and solid dosage form. This method were extended to pharmaceutical formulations and there no interference from excepients and diluents. The proposed methods are economical ...

Abstract  Simple, sensitive and precise spectrophotometric methods have been developed for the estimation of val acyclovir, aceclofenac, racecadotril, valdecoxib, nebivolol and reboxetine in bulk and pharmaceutical dosage forms. Methanol and triple distilled water were used as solvents for the estimation of all these drugs. Absorption maxima of all the above drugs were determined and the estimations were carried out in tablet dosage forms. Results of the analysis were validated statistically and by recovery studies.