Development and validation of UV- Spectroscopic met hod for estimation of Voglibose in bulk and tablets


Abstract

Simple, rapid, sensitive and accurate UV- Spectrophotometric methods have been developed for estimation of Voglibose in pharmaceutical formulation. Since Voglibose only absorbs UV in the low wavelength region, it cannot be detected with high sensitivity. So special detection methods are necessary for analysis of Voglibose. Voglibose shown effective results for various analytical instruments only in the combination of Taurine and Sodium period ate. Drug solution was derivatized using Taurine and Sodium period ate in water and methanol. Drug exhibited distinct λmax in methanol at 282nm. Linearity was observed in the concentration range 10-80 μ g/ml. (r2= 0.997). Amounts of drug estimated from tablet formulation were in good agreement with label claim. The method was validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of voglibose in bulk and tablet dosage forms.

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