Thiadiazoles: Progress Report on Biological Activit ies
Abstract Several five member-ed aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities. This review article covers the most active thiadiazole derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory, anticancer, anti convulsant, antidepressant, antioxidant, radio protective and anti-leishmanial. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in terms of efficacy and safety. For more info: http://www.jocpr.com/articles/thiadiazoles-progress-report-on-biological-activities.pdf