Journal of Chemical and Pharmaceutical Research

Abstract    Several five member-ed aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities. This review article covers the most active thiadiazole derivatives that have shown considerable biological actions such as antimicrobial, anti-inflammatory, anticancer, anti convulsant, antidepressant, antioxidant, radio protective and anti-leishmanial. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an important tool for medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in terms of efficacy and safety.  For more info: http://www.jocpr.com/articles/thiadiazoles-progress-report-on-biological-activities.pdf

Leucotrienes have attracted the attention of physician, medicinal chemist and pharmacist for its versatile biological activities.The present review highlights physiological and pathophysiological aspects of Leucotrienes. Leukotrienes, together with the prostaglandins and other related compounds, are derived from 20 carbon (eicosa) fatty acids that contain double bonds (enoic). They are formed from the breakdown of arachidonic acid, a polyunsaturated 20 carbon fatty acid. In its esterified form, arachidonic acid is bound to the phospholipids of the cell membranes. Both immunological and non-immunological stimuli can release arachidonic acid from membrane phospholipids by activating phospholipase A2.There is wide scope of Leukotrienes in therapeutic efficacy against many diseases, hence in this regard the review is outlined to collect the data of history of Leukotrienes releated to its molecular study, structure, pathophysiology and application. it is very interesting and note worthy t...