Leucotrienes and Its Biological Activities: A Review

Leucotrienes have attracted the attention of physician, medicinal chemist and pharmacist for its versatile biological activities.The present review highlights physiological and pathophysiological aspects of Leucotrienes. Leukotrienes, together with the prostaglandins and other related compounds, are derived from 20 carbon (eicosa) fatty acids that contain double bonds (enoic). They are formed from the breakdown of arachidonic acid, a polyunsaturated 20 carbon fatty acid. In its esterified form, arachidonic acid is bound to the phospholipids of the cell membranes. Both immunological and non-immunological stimuli can release arachidonic acid from membrane phospholipids by activating phospholipase A2.There is wide scope of Leukotrienes in therapeutic efficacy against many diseases, hence in this regard the review is outlined to collect the data of history of Leukotrienes releated to its molecular study, structure, pathophysiology and application. it is very interesting and note worthy to develop Leukotrienes for its medicinal values.

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