Journal of Chemical and Pharmaceutical Research

ABSTRACT A series of novel substituted benzimidazole derivatives by the condensation of different diamines with anthranilicacid were synthesized. The subsequent reactions of the benzimidazole derivatives were reacted with different aromatic acid chloridesto get tetrazole moieties. These compounds were screened for their potential anti-cancer, anti-diabetic, anti-tumor and anti- asthmatic properties, which exhibited some authentic results towards testing organism invitro and invivo studies.

Abstract  The Synthesis of 5-methyl -2,4-dihydro-3H-pyrazole-3-one is prepared by the cyclisation reaction between etylaceto acetate and hydrazine hyd rate in absolutealcohol.(compound 1). 5-methyl -2,4-dihydro-3H-pyrazole-3 one react with substituted benzaldehyde to prepare4-(4-substitutedbenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (compound 2) . 4-(4-substituted benzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and substituted benzoyl chloride and substituted benzene sulfonyl chloride and add Triethylamine1 to2 drops and stirring for 4 hr and evaporate Trietylamine on water bath and product of (4-Substituted benzylidene)-3-methyl-1-(Substituted Phenyl Sulfonyl and substituted benzoyl)-1H-pyrazol-5(4H)-one(compound 3 and 4)obtained  For more info: http://www.jocpr.com/articles/synthesis-and-biological-evaluation-of-4substituted-benzylidene3methyl1substituted-phenyl-sulfonyl-and-substituted-benzo.pdf