Synthesis and biological evaluation of(4-substituted benzylidene)-3-methyl-1-(substituted phenyl sulfonyl and substituted benzoyl)-1H-pyrazol-5(4H)-one as anti-inflammatory agent


Abstract 

The Synthesis of 5-methyl -2,4-dihydro-3H-pyrazole-3-one is prepared by the cyclisation reaction between etylaceto acetate and hydrazine hydrate in absolutealcohol.(compound 1). 5-methyl -2,4-dihydro-3H-pyrazole-3 one react with substituted benzaldehyde to prepare4-(4-substitutedbenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (compound 2). 4-(4-substituted benzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and substituted benzoyl chloride and substituted benzene sulfonyl chloride and add Triethylamine1 to2 drops and stirring for 4 hr and evaporate Trietylamine on water bath and product of (4-Substituted benzylidene)-3-methyl-1-(Substituted Phenyl Sulfonyl and substituted benzoyl)-1H-pyrazol-5(4H)-one(compound 3 and 4)obtained 

For more info:http://www.jocpr.com/articles/synthesis-and-biological-evaluation-of-4substituted-benzylidene3methyl1substituted-phenyl-sulfonyl-and-substituted-benzo.pdf 


Comments

Post a Comment

Popular posts from this blog

Synthesis of Atenolol Impurities

Image
ABSTRACT: The aim of this research was to synthesis impurities of Atenolol viz. 2-(4-Hydroxy phenyl acetamide(Impurity A) , 2- [4-[[(2RS)oxiran-2-yl]methoxy]phenyl] acetamide (Impurity C) and 2-[4-[(2RS)-3-chloro-2-hydroxypropxy] phenyl]acetamide (Impurity D ) by very conventional method. Further details Home page URL:   http://www.jocpr.com/ For more details PDF Link :    http://www.jocpr.com/articles/synthesis-of-atenolol-impurities.pdf
Read more

Evaluation of acrylate-sunflower oil copolymer as viscosity index improvers for lube oils

Image
ABSTRACT: Copolymers of sunflower oil with methyl methacrylate and decyl acrylate were synthesized and characterized. Intrinsic viscosity and viscometric molecular weight were determined by using Huggins and Mark- Houwink equation respectively. Viscosity index (VI) of the additive doped base oils were evaluated and compared with that of the mineral base oils. VI values of the additive doped base oils depend on the nature of mineral base oils used and the type and concentration of VI improvers. For a comparison, respective homopolymers e.g. polymer of sunflower oil, poly(methyl methacrylate) and poly(decyl acrylate) were also prepared, characterized and evaluated in the similar fashion. For more details PDF Link:  ht tp://www.jocpr.com/articles/evaluation-of-acrylatesunflower-oil-copolymer-as-viscosity-index-improvers-for-lube-oils.pdf Further details:  h ttp://www.jocpr.com/
Read more

Hepatoprotective and antioxidant efficacy of Anethum graveolens linn in carbon tetrachloride induced hepatotoxicity in albino rats

Image
ABSTRACT: In the present study, the hepatoprotective and antioxidant efficacy of Anethum graveolens Linn was evaluated in CCl4 induced hepatotoxicity in albino rats. Hepatotoxicity was induced in albino rats by subcutaneous injection of carbon tetrachloride. Hepatoprotective efficiency of 100 mg/Kg wt of ethonalic extract of Anethum graveolens Linn was evaluated. Hepatotoxicity in experimental rats was evidenced by enhancement in the activity of SGOT, SGPT, MDA, & ALP and significant decrease in the activity of GSH, GPX, SOD & CAT. In plant extract treated animals, the toxicity effect of CCl4 was controlled significantly by restoration of the activity of above serum enzymes and antioxidant enzymes compared to the normal and standard drug silymarin treated groups. Therefore the results of present study support the hepatoprotective effect of Anethum graveolens Linn. For more details Home Page URL: http://www.jocpr.com/ Further detail PDF Link:  http://www.jocpr...
Read more