Journal of Chemical and Pharmaceutical Research

ABSTRACT Poloxamer 407 is used primarily as a thickening agent and gel former, but also as a co-emulsifier and consistency enhancer in creams and liquid emulsions. It is also used as a solubilizer for certain active substances Moreover, Poloxamer 407 is suitable for the formulation of active substances that show reduced solubility as a result of neutralization. Poloxamer 407 is reported to possess transparency, film forming properties and useful in formation of gel. The aceclofenac gels were prepared by using different concentration of Poloxamer 407 for topical drug delivery with an objective to increase transparency and spreadability.

Abstract  The present study objective was to develop novel colon specific drug delivery systems for aceclofenac using pectin as a microbially degradable polymeric carrier and to coat the optimized batches with a pH dependent polymeric coating solution containing Eudragit L 100 and S 100 (1:4). Pellets containing four proportions of pectin were prepared. The pellets were evaluated for physicochemical properties, drug content, dissolution, water uptake & erosion characteristics,in vitro drug release studies. The amount of aceclofenac released from the pectin pellets at different time intervals was estimated by UV spectrophotometric method at 275nm. Eudragit coated pectin pellets prevented release of the aceclofenacin the physiological environment of stomach and small intestine depending on the proportion of pectin used in the formulation. The dissolution profile and in vitrorelease kinetics showed that pectin pellets were promising for controlled delivery of the drug. Th...