Formulation Development and Characterization of Ace clofenac Gel Using Poloxamer 407

ABSTRACT
Poloxamer 407 is used primarily as a thickening agent and gel former, but also as a co-emulsifier and consistency enhancer in creams and liquid emulsions. It is also used as a solubilizer for certain active substances Moreover, Poloxamer 407 is suitable for the formulation of active substances that show reduced solubility as a result of neutralization. Poloxamer 407 is reported to possess transparency, film forming properties and useful in formation of gel. The aceclofenac gels were prepared by using different concentration of Poloxamer 407 for topical drug delivery with an objective to increase transparency and spreadability.

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