Journal of Chemical and Pharmaceutical Research

ABSTRACT: Two innovative, new, simple and low cost UV-spectrophotometric and first order derivative methods were developed and validated for estimation of Galantamine Hydrobromide in bulk drug and tablet dosage form. Galantamine Hydrobromide was estimated at 289 nm in Distilled Water. In first order derivative, it showed amplitude at 284.8 nm and λminima = 290.4 nm with 286.4 nm as zero crossing point (ZCP). In both the methods linearity was found to be in the range of 20-100 µg/ml; for UV spectrophotometric method (y = 0.007x - 0.002, r² = 0.999) and for first order derivative spectrophotometric method (Y=0.0012 x+0.00045; r2=0.999), respectively. These methods were analyzed and validated for various validation parameters according to USP guidelines. The quantitation limits were found to be 0.50 and 1.54 µg/ml, for UV-Spectrophotometric method and 3.3 and 10 µg/ml for the 1st order derivative method. The proposed methods were successfully applied for the determination of Galant...

ABSTRACT: A rapid, sensitive and specific RP-HPLC [1-5] method involving UV detection was developed and validated for determination and quantification of Lamivudine and Zidovudine. Chromatography was carried out on a pre-packed AltimaC18 5µ (150*4.6mm) column using filtered and degassed mixture of Ammonium acetate buffer:Methanol (80:20) as mobile phase at a flow rate of 1.0ml/min and effluent was monitored at 270nm. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of quantification and limit of detection. The assay was linear over the concentration range of Lamivudine and Zidovudine was 37.5mcg-112.5mcg/ml and 75mcg to 225mcg/ml respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analyzed test solution and was found to be 98.50%-99.9% and 98.30%- 100.10% within precision RSD of 0.71 and 0.82 for Lamivudine and Zidovudine respectively. The system suitability...

ABSTRACT: Metal chelates of biologically important Schiff bases namely 4-methyl-2-{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol(MEMIIMP) and 5-methoxy-2--{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol(MMIIMP) with Cu(II), Ni(II), Co(II), Zn(II) and VO(IV) have been synthesized. The metal chelates have been characterized by elemental analysis molar conductivity data TG, DTA, spectral (IR, 1H-NMR, Mass, ESR and electronic) and magnetic moments. The dissociation constants of Schiff bases and stability constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes have been determined potentiometrically in aquo organic medium at 30±1oC and at 0.1 M KNO3 ionic strength. Antimicrobial activities of Schiff bases and their complexes were screened against bacteria & fungi are discussed. Introduction :   Studies on a new kind of chemotherapeutic Schiff bases are now attracting the attention of biochemists. Schiff base complexes derived from 4-hydroxy salicylal...

ABSTRACT: Ever since the accessibility of modern medicine increased all over the world, the rampant and misuse also increase considerably. A continuous research resulting in introduction of the newer compounds is going on. Many of these are being introduced and used without complete of drugs. The pharmacist because of different reasons is unable to practice the rational drug therapy that is supply right drug, at right time in right dose to the patient. The present article takes the help of some published reports to explain irrational or misuse of drug leading to fatal effect. The article also highlights the major reasons involved in the irrational use of drugs. Not only the irrational use but the drugs having the adverse reaction and hazardous effects are also used in large amount in developing nations due regulatory reasons. The use of these drugs without the complete knowledge has also a major problem. In this article the author has given emphasis on the drug hazards and ratio...

ABSTRACT: Many natural products from marine sources are endowed with promising anti hypertensive activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted used in treatment of hypertension Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/recent-synthesis-of-marine-natural-products-with-antihypertensive-activity-an-overview.pdf

Abstract QSAR (Quantitative Structure Activity Relationship)studies were carried out on a set of 61 N-(2-aryl-cyclohexyl) and N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 inhibitors (Glycine Transporter1) using multiple regression procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures such as external set cross-validation r 2 (R 2cv,ext ) and the regression of observed activities against predicted activities and vice versa for validation set were described to analyse the predictive ability of the QSAR model. An accurate and reliable QSAR model involving six descriptors was chosen based on the FIT Kubinyi function. Applicability domain of QSAR model such as leverages, y-randomization test and RMSE (Root Mean Square Error) of training and validation set were reported