Journal of Chemical and Pharmaceutical Research

Abstract Ethyl 4-piperidone reacts with different amines in presence of toluene as a solvent and water is removed and Schiff base is formed. Then this Schiff base undergoes reduction and reduced product of Schiff base is obtained. Then it is undergoes for benzoylation, After benzoylation It reacts with two different azides and forms again Schiff base for both azides which further undergoes for clemensen reduction. The reduction product of both azides reacts with ethyl acetoacetate and undergoes cyclization and formed to get the desired cyclized product. product for antifungal screening by zone of inhibition study respect to some gram positive and gram negative microbes reference standard antibiotics. The satisfactory result has been found in the antifungal screening. 

Abstract  Indanone acetic acid is a non-heterocyclic fused ring of benzene with cyclopentananone moiety with acetic acid side chain in 1-position. This specific moiety has been synthesised and condensed with various substituents like PABA, piperidine, morpholine, benzimidazole, piperazine, pyrazolone and hydrazine to get the desired product for animicrobial screening by zone of inhibition study and MIC values with respect to some gram positive and gram negative microbes and fungal strains with reference standardantibiotics. The satisfactory result has beenfound in the antimicrobial and antifungal screening. 

A new series of Anti bacterial and Antifungal agents with 2-(5-amino-1, 3, 4-thiadiazol-2-yl) phenol as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by IR and 1HNMR spectral methods. The compounds were screened for antibacterial activity against pathogenic microbes Bacillus subtilus, Staphylococcus aureus, E.coli, in comparison with the reference drug Ampicillin, Ciprofloxacin and Doxycycline and antifungal activity against Candida albicans and comparable to that of Fluconazole as a reference drug and in this investigation the significant level of activity was illustrated. PDF