UV- Spectrophotometric determination of Ceftazidime in pure and pharmaceutical formulation


Abstract 

A simple sensitive spectrophotometric method in UV region has been developed for the determination of Ceftazidime in bulk dosage form. The solution of ceftazidime in 0.1N HCl shows maximum absorbance at 261nm, beer’s law was obeyed in the concentration range of 2-10 μg ml-1. The absorbance was found to increase linearly with increasing concentration of ceftazidime, which is corroborated by the calculated correlation coefficient value of 0.9981. The slope and intercept of the equation of the regression line are 0.0465 and 0.0007 respectively. The analysis were validated statistically and its recovery studies result of percentage shows that the method was not affected by the presence of excepients which proves suitability of the developed method for the routine estimation of ceftazidime bulk and solid dosage form. This method were extended to pharmaceutical formulations and there no interference from excepients and diluents. The proposed methods are economical and sensitive for the estimation of ceftazidime in bulk dosage form


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