Synthesis, Antibacterial and invitro Antioxidant Activity of 2,3-Substituted Quinazolin-4(3 H )-ones


Abstract 

Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, antitumor, antioxidant and anti-HIV activity. Schiff bases have also been exploited extensively for antimicrobial and antioxidant activities. In the present investigation various quinazolinone amines have been clubbed with five membered heterocyclic aldehydes to obtain the title compounds. All the synthesized compounds have been screened for their antibacterial activity against S.aureus, B.subtilis, E.coli and K.pneumoniaand invitroantioxidant activity by 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method.

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