Selective Extraction of 7-aminodeacetoxycephalospor anic acid and Cephalexin antibiotics with Aliquat-336

ABSTRACT
The reactive extraction of7-ADCA (aminodeacetoxycephalosporanic acid) and Cephalexin with Aliquat-336 (tricaprylmethyl ammonium chloride) dissolved in n-butyl acetate as solvent has been studied over a pH range of 5 to 8. The effect of such parameters as Aliquat-336 concentration, pH and 7-ADCA and Cephalexin concentrations on distribution coefficient in the reactive extraction system has been evaluated. It was found that distribution coefficient (Kd) increases with increases of the aqueous phase pH implying that the anionic forms of the dissociated 7-ADCA and cephalexin are amendable forreactive extraction.

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