Conventional and Greener Approach for the Synthesis of Some Novel Substituted -4-Oxothiazolidine and Their 5-Aryliden e Derivatives of 2-Methyl-benzimidazole: Antimicrobial Activities
Abstract
The aim
of this work was to investigate the efficiency of N1–(2-Benzylidene-imino-5'-methylene)-1',3',4'-thiadiazole]-2-methyl-benzimida
zoles, 4(a-n);
N'1-[2'-{2-Substituted-Phenyl-1,3-thiazolidin-4-one}-5'-methylene-1',3',4'-thiadiazole]-2-methyl-benzimidazoles,
(a-n)and N1-[2'-{2-substituted-phenyl-5-substituted-benzylidene-1,3-thiazolidine-4-one}-5'-methylene-1',3',4'-thiadiazole]
-2-methyl-benzimidazoles, 6(a-n)for the synthesis by conventional and greenar
approach methods in terms of yield and reaction time along with antimicrobial
activity against Bacillus subtilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus
aureus bacteriaand Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and
Trichoderma viridefungi in vitro at 50 and 100 ppm concentrations.Some of the
compounds displayed pronounced biological activity. The structures of all the
new compounds were established on the basis of elemental analysis and spectral
data (IR, 1HNMR and mass).
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