Anti-tumor activity of N4 [(E)-1-(2-hydroxyphenyl)methylidene]iso -nicotinohydrazide and Its Ti (IV) and Cu (II) complexes on K562 and Jurkat

ABSTRACT:

N 4 [(E)-1-(2-hydroxyphenyl)methylidene] isonicotinohydrazide abbreviated as NHPM were synthesized and characterized. Ti(IV) and Cu(II) metal complexes of this ligand prepared by reaction of fluoride salt of Ti(IV) and acetate salt of Cu(II) with NHPM in dry acetonitrle. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR and UV–Visible spectroscopy. These new complexes showed excellent antitumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.

Introduction:

 Presently, there is a growing interest in the coordination chemistry of structurally modified bio-ligands. Transition metal complexes with potential biological activity are the focus of extensive investigations . Metal complexes of biologically important ligands are sometimes more effective than the free ligands . Metal based drugs have been used in medicine for many centuries, but very often only in an empirical fashion. Nowadays there is enormous scope for the design of novel therapeutic compounds, for example, the well known cis-platin is a transition metal based drug which forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, inducing DNA cross-links that result in apoptosis and cell growth inhibition . Due to the severe adverse effects of cis-platin, researchmoved to a second-generation of platinum compounds like carboplatin, nedaplatin, satraplatin and other closely related platinum antitumor agents, some of which are still used for the treatment of certain types of tumors. It has long been known that metal ions involve in biological processes of life and have been subject of interest. The modes of action of these metal ions are often complex but are believed to involve bonding to the hetero-atoms of the heterocyclic residues of biological molecules, i.e., proteins, enzymes, nucleic acids, etc. Schiff bases and their metal complexes played an important role in the development of coordination chemistry, resulting in an enormous number of publications, ranging from pure synthetic work to physicochemical and biochemically relevant studies of metal complexes and found wide range of applications.

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