Innovations in Sustained Release Drug Delivery System and Its Market Opportunities


ABSTRACT:

Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. In the recent years, focus on the development of controlled release drug delivery systems has increased. The basic rationale of controlled release drug delivery system optimises the biopharmaceutical, pharmacokinetic, and pharmacodynamic properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure or control of the condition is achieved, in the shortest possible time by using smallest quantity of drug administered by the most suitable route. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilisation of the drug, increased safety margin of potent drug, reduction in healthcare costs through improved therapy, shorter treatment period and less frequency of dosing. SR products are designed to bring the blood level of a drug immediately to therapeutic concentrations by means of an initial dose portion and then sustain this level for a certain predetermined time with the maintenance portion .SR of drugs in gastrointestinal tract following oral administration is not affected by the absorption process. SR oral dosage forms have become more important in therapy as a means of reduced dosing frequency, hence potentially improving patient compliance and consequently efficacy. The principal goal of SR dosage forms is the improvement of drug therapy assessed by the relationship between advantages and disadvantages of the use of SR systems.

For more details @ http://www.jocpr.com/articles/innovations-in-sustained-release-drug-delivery-system-and-its-market-opportunities.pdf


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