In-Vitro Evaluation of prepared Topical Gel of Nimesulide
ABSTRACT:
Nimesulide is a second generation non–steroidal
anti–inflammatory agent, which is widely used in the long term therapy of
rheumatoid arthritis, in alleviating pain and inflammation. But its short
half-life (only 3–4hrs.), so its causes more fluctuation. After oral
administration Nimesulide causes to produces heart burn, nausea, loose motions,
pruritus, etc. The present study based on the preparation of bioadhesive
topical gel of Nimesulide, so as to avoid all gastric side effects. For the
preparation of bioadhesive topical gel natural polymer aegel marmelos (plant
Bale) was used. Bioadhesive polymers are the agents which increases the contact
between the formulation and biological membrane, so as to avoid the fluctuation
of formulation and behave as a sustained release formulation. In the present
study, prepared bioadhesive topical gel was evaluated with the help of
different parameters like drug content, spreadability, extrudability, swelling
index study, in–vitro drug diffusion study, in-vitro drug release kinetic study
and ex– vivo bioadhesive measurement. On the basis of in–vitro drug diffusion
study and ex–vivo bioadhesive measurement property of gel, we have concluded
that natural polymer aegel marmelos is the best polymer for the preparation of
sustained release bioadhesive topical gel.
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