Studies on enteric coated sustained timed-release t ablets of Metronidazole


Abstract 

The present article deals with an oral dosage form proposed for the attainment of timed release drug delivery of metronidazole. Metronidazole containing matrix tablets coated with 3,4,5 & 6% w/v cellulose acetate phthalate in acetone were examined for applicability as timed release tablets with a predetermined lag time of 4-5 hrs. Different types of enteric coated tablets were prepared and there drug dissolution profile was studied in 0.1 N HCl (0 to 2hr) and PBS 6.8 (2-24 hr) as dissolution media at 37±0.5 ºC,100 rpm byUSP Apparatus-1(Basket assembly). The result indicated that the tablets with timed release functions could be prepared and,that the lag time were increased as the coat concentrations increased (3% to 6%w/v).

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