Design development and evaluation of extended release tablets of Alfuzosin hydrochloride

Alfuzosin hydrochloride(HCl) was formulated as oral extended release matrix tablets using polymers like sodium alginate, ethyl cellulose( EC), hydroxyl propyl methyl cellulose (HPMC K100) and hydrogenated castor oil (HCO).Matrix tablets were prepared by wet granulation method. Tablets were prepared with drug to polymer ratios 1:5, 1:10, 1:15 and 1:20.The formulated tablets were evaluated for various physicochemical parameters by official procedures. The in vitro release study of the matrix tablets were carried out in 0.1N HCl for 2hrs at pH 1.2 and pH 6.8 buffer for the next 22 hours. Based on drug release rate, polymers can be arranged as sodium alginate > EC >HPMC >HCO. Among all the polymers HCO was most suitable to design the extended release formulation of alfuzosin HCl. Analysis of drug release mechanism indicated that the drug release from the matrix tablets was found to be non fickian obeying zero order kinetics.

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