Design, synthesis and biological evaluation of benzoxazole derivatives as new antiinflammatory agents

New series of methyl 2-(arylideneamino) benzoxazole -5-carboxylate derivatives were synthesized by the reaction of Schiff bases of methyl 2-aminobenzoxazole-5-carboxylate with appropriate aromatic aldehydes. The chemical structures of the synthesized compounds were confirmed by means of IR, 1HNMR, mass spectral analysis. Further, the synthesized compounds (SH1-SH9) were screened for antiinflammatory activity by using Carrageenan – induced paw edema rat model. The results showed that, compounds SH1-SH3 and SH6-SH8 were significantly (p<0.0001) reduced the inflammation there by showed a promising antiinflammatory activity; where as the compound SH5 moderately reduced the inflammation. Only the two compounds i.e SH4 and SH9 showed very poor anti-inflammatory activity towards Carrageenan – induced paw edema rat.

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