Microwave assisted synthesis of some 5-pyridyl-2-[(N-substituted phenyl) thioacetamido]-1,3,4-oxadiazoles as antibacterial and antioxidant agents

Several substituted 1,3,4-oxadiazole exhibit antibacterial, antimicrobial pesticidal, anti-mycobacterial, anti-inflammatory and anti-fungal activities. Recently microwave assisted synthesis has attracted the researcher throughout the world for its less time consumption, minimum usage of solvents and increased yield of the compounds. The present investigation was to synthesize the title compounds 5-pyridyl-2-[(N-substituted phenyl) thioacetamido]-1,3,4- oxadiazoles (4a-g) by conventional and microwave methods and evaluate their antibacterial and antioxidant activities. It is well known that free radicals play an important role in the inflammatory process.

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