Synthesis, characterization and bioactivities of Ni(II) and Co(II) complexes of benzyloxybenzaldehydethiosemicarbazone

Ni(II) and Co(II) complexes of benzyloxybenzaldehydethiosemicarbazone(L) were prepared and characterized by their physical, spectral and analytical data. The newly synthesized metal complexes have a composition of [M(L)2X2], where M= Co(II) or Ni(II) and X= Cl. The electronic spectral studies show an octahedral geometry around Ni(II) and Co(II) complexes. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination with the central metal ion. In order to evaluate the biological activity of the ligand and its metal, complexes have been screened for their antibacterial and antifungal activity against bacterial species like – B.subtilis and S.aureus(Gram-positive bacteria) and E. coli, P. aeruginosa and P. vulgaris (Gram-negative bacteria) and also fungal species like- Microsporumgypseum, Teloschistes villous, Aspergillus fumigates and Candida albicans. The results of antimicrobial studies clearly show that the process of chelation dominantly affects the overall biological behaviour of the compounds and they are potent against bacterial and fungal strains. The free ligand and its corresponding metal complexes were screened for antioxidant properties by radical scavenging methods such as 1,1-diphenyl -2-picryl hydrazyl (DPPH) and lipid peroxidation. They exhibited potent invitro - antioxidant activity dose dependently.

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