Observation of the release of aspirin from gelatin-sodium alginate polymeric implant

ABSTRACT:

Implantation technology is currently the most utilized route for studying sustained drug release potential. Present investigation explores the scope of sustaining the release of drug by using Gelatin-Sodium Alginate combination biodegradable implants. Implants were formulated in varied ratios of Gelatin and Sodium alginate, i.e. 70:30, 80:20 and 90:10 % w/w by heating and congealing method. They were then exposed to formaldehyde for different time periods, (3 Hrs, 6 Hrs, 12 Hrs and 24 Hrs) for hardening. Aspirin was chosen as the model drug because it plays an important role in treating many long term conditions like rheumatoid arthritis, myocardial infarction, stroke and cancer. The implants were evaluated for thickness, weight variation, presence of free formaldehyde and in-vitro release studies over a period of 96 hours (4 days). The implant formulated with 80:20 Gelatin-Sodium Alginate ratio and hardened for 12 hours with formaldehyde were found to produce the maximum sustained action for 96 hours (4 days). Tests for free formaldehyde revealed that none of the implants contained free formaldehyde. The results of invitro dissolution study were fitted to different kinetic models to evaluate the kinetic data. The kinetic data was determined by finding the best fit of the release data to these models. Implants were found to follow the Higuchi model of kinetics the best. Also good correlations were obtained with Korsmeyer-Peppas model. Therefore, drug release from the implants was diffusion-controlled, where the drug was found to leave the matrix through pores and channels formed by the entry of dissolution medium.

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Further details PDF Link: http://www.jocpr.com/articles/Observation-of-the-release-of-aspirin-from-gelatinsodium-alginate-polymeric-implant.pdf

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