Solid State Characterization of Ceftiofur Sodium Polymorph

ABSTRACT:
The present study deals with the solid state characterization of novel Ceftiofur Sodium having moisture content in the range of 5.0-8.0%. Here the analytical challenge is to determine the exact hydration state, i.e. Dihydrate or Hemipentahydrate or Trihydrate. Based on the results of vacuum assisted PXRD, DSC, TGA, DVS and HSM the hydration state was confirmed as trihydrate wherein one mole in the lattice, forms channel hydrate and two moles are possibly present as ion-associated.



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Further details PDF Link: http://www.jocpr.com/articles/solid-state-characterization-of-ceftiofur-sodium-polymorph.pdf

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