Protective effect of Eclipta alba on haloperidol induced extrapyramidal movement disorders in albino rats


ABSTRACT:

 Extrapyramidal movement disorders are major neurodegenerative disorders caused due to dopamine deficiency in the basal ganglia. It may be caused due to oxidative stress producing free radicals that destroys dopamine producing neurons. Catalepsy, Tardive dyskinesia etc are the symptoms of certain nervous disorders such as Parkinson’s disease & epilepsy in animal models. Phytochemical analysis of Eclipta alba (Bhringaraj) shows that it contains urosolic acid having antioxidant properties. The present study was undertaken to evaluate the possible protective effect of Eclipta alba leaf extract (EALE) on oxidative stress & haloperidol induced extrapyramidal symptoms. Male wistar albino rats (150-200gms) were used for the experiments. Catalepsy was induced with haloperidol (1mg/kg IP) using block method & was measured by standard procedure of Zazpe etal 2006. 

Effect of EALE in a dose of 100,200,400mg/kg on haloperidol induced catalepsy &vacuous chewing movements (VCM) were measured and compared with the standard drug alpha tocopherol. The effect of EALE on oxidative stress was done by estimating the catalase & glutathione activity. Analysis was done by suitable statistical methods. The cataleptic score & VCM were significantly reduced with all the three doses of EALE. There was significant reduction of catalase activity whereas increase in glutathione activity with EALE. The antioxidant properties of Eclipta alba reduced the duration of catalepsy, number of VCM, decreased the elevated levels of lipid peroxidation in the haloperidol treatment groups & elevated the cellular defense mechanism such as glutathione that proves its anticataleptic activity.

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For more details PDF Link: http://www.jocpr.com/articles/protective-effect-of-eclipta-alba-on-haloperidol-induced-extrapyramidal-movement-disorders-in-albino-rats.pdf


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