Simultaneous estimation of gatifloxacin and flurbiprofen sodium in ophthalmic formulation by UV - Spectrophotometric method


ABSTRACT:

A UV- Spectrophotometric method has been developed for the determination of Gatifloxacin and Flurbiprofen Sodium in their pharmaceutical formulation on measurement of absorbance at two maximum Gatifloxacin respectively. The method was validated for various parame regression analysis data for the calibration plots showed good linear relationship 18 µg/ml and 0.6 – 1.8 µg/ml and correlation co Flurbiprofen Sodium respectively.

Further details Home Page URL:  http://www.jocpr.com/

For more details PDF Link: http://www.jocpr.com/articles/simultaneous-estimation-of-gatifloxacin-and-flurbiprofen-sodium-in-ophthalmic-formulation-by-uv-specrophotometric-method.pdf
  


Comments

Post a Comment

Popular posts from this blog

Phytochemical investigation of the roots ofGrewia microcosLinn.

Image
ABSTRACT: The present study reports the phytochemical investigation of the roots of Grewia microcos linn. Seven Phytoconstituents have been reported namely 9,12- octadecadienoic acid; Ursolic acid; Stigmasterol; 6,4- dihydroxy-3-propen chalcone; Dioctyl phthalate; N-methyl-6-β-(1’,3’,5’-trienyl)-3-β-methoxyl-3-β-methyl piperidine; and Dibutyl phthalate have been reported for the first time from the roots of Grewia microcos. Further details Home page URL : http://www.jocpr.com/ For more details PDF Link : http://www.jocpr.com/articles/phytochemical-investigation-of-the-roots-of-grewia-microcos-linn.pdf
Read more

Synthesis of Atenolol Impurities

Image
ABSTRACT: The aim of this research was to synthesis impurities of Atenolol viz. 2-(4-Hydroxy phenyl acetamide(Impurity A) , 2- [4-[[(2RS)oxiran-2-yl]methoxy]phenyl] acetamide (Impurity C) and 2-[4-[(2RS)-3-chloro-2-hydroxypropxy] phenyl]acetamide (Impurity D ) by very conventional method. Further details Home page URL:   http://www.jocpr.com/ For more details PDF Link :    http://www.jocpr.com/articles/synthesis-of-atenolol-impurities.pdf
Read more

A Validated specific Stability-indicating RP-HPLC method for Aripiprazole and its related substances

Image
ABSTRACT : A validated specific stability indicating reversed-phase liquid chromatographic method was developed for the quantitative determination of Aripiprazole and its related substances in bulk samples, pharmaceutical dosage forms in presence of degradation products. Forced degradation studies were performed on bulk sample of Aripiprazole as per ICH prescribed stress conditions using acid, base, oxidative, thermal stress and photolytic degradation to show the stability indicating power of the method. Significant degradation was observed during basic stress and no degradation was observed in other stress conditions. The chromatographic method was optimized using the samples generated from forced degradation studies and the impurity spiked with Aripiprazole. Good resolution between the peaks corresponds to impuritiy-1, degradation products from the analyte were achieved on YMC PACK C18 column using the mobile phase consists a mixture of Sodium dihydrogen Orthophosphate dehydra...
Read more