Ultrasound-promoted synthesis of 2-aminothiophenes accelerated by DABCO utilizing PEG-200 as solvent

ABSTRACT:

An expeditious and greener one-pot procedure was developed for the synthesis of multisubstituted 2-aminothiophene derivatives. In the presence of catalytic amount of DABCO, ketones or aldehydes, dicyanomethane and elemental sulfur were converted into the corresponding 2-aminothiophene derivatives in moderate to high yields in PEG-200 under sonication.


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For more details PDF Link: http://www.jocpr.com/articles/ultrasoundpromoted-synthesis-of-2aminothiophenes-accelerated-by-dabco-utilizing-peg200-as-solvent.pdf




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