A Facile β-Cyclodextrin-Catalyzed synthesis of substituted benzofuran from salicyaldehyde and alpha tosyl ketone


ABSTRACT:

enzofuranones have attracted considerable attention with regard to their pharmaceutical activity and the various approaches directed towards their synthesis 1 .The simple benzofuran derivatives like 2-nitrobenzofuran2 , 2-acetyl benzofurans are well known as bio-dynamic agents possessing various pharmacological propertiesi.e.spasmolytic activity on the intestine of the guinea pig3 and dilatory effects on the heart of the rabbit4 . Most of the benzofuran compounds frequently occur in natural products and are good chelating agents. The compound amiodarone hydrochloride used as an idealantiarrhythmic drug5 contains a 2, 3-substituted benzofuran moiety. The Schiffs bases exhibit a broad spectrum of pharmacological and biological properties6 such as analgesic, anticancerous, antiinflammatory etc. that may be due to the azomethine linkage. The Schiffs bases bearing methoxy groups have pronouncedantimicrobial activities7 . The Schiffs bases derived from sulfa drugs and salicylaldehydes act as good chelating, bactericidal and fungicidal agents.

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