Concentration change and clinical significance of plasma S100 protein in cardiopulmonary bypass perioperative period


ABSTRACT:

To seek for evaluation indicators of cerebral injury in cardiopulmonary bypass (CPB) perioperative period and discuss the change and clinical significance of S100 protein in CPB perioperative period. 40 patients of congenital heart disease or heart valve disease were subject to open-heart surgery under CPB. The occurrence of neurological complications in perioperative period was observed. The concentration of plasma S100 protein was measured at different time points in CPB perioperative period. 3 cases of neurological complications occurred after surgery, including 2 cases of mental symptom and 1 case of cerebral infarction. The start of CPB caused great increase of S100 protein plasma concentration which recovered to the preoperative level 24 to 48 hours after surgery. Patients with neurological complications had a significantly higher S100 protein concentration than those without neurological complications and their S100 protein concentration still maintained a high level 24 hours after surgery. CPB can cause significant increase of plasma S100 protein level and has important clinical significance for the evaluation of cerebral injury after surgery.


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