Synthesis, physicochemical and biological evaluation of Co (II) complexes derived from 5-chloro-2-hydroxy acetophenone N(4) methyl thiosemicarbazone


ABSTRACT:

Heterocyclic base adducts of cobalt (II) complexes have been synthesized by the reaction of cobalt (II) chloride with 5-chloro-2-hydroxy acetophenone N(4) methyl thiosemicarbazone in presence of heterocyclic base like pyridine (py), 2,2’-bipyridine (bipy), 1,10-phenanthroline (Phen), α/β-picoline. The synthesized thiosemcarbazone has been characterized by 13C, 1H NMR as well as IR, electronic spectra. The magnetic and spectroscopic study show octahedral geometry for six coordinate, square planner geometry for the four coordinate and a distorted square pyramidal for five coordinate complexes. The thiosemicarbazone and its cobalt (II) complexes exhibit growth inhibitory activity against Pseudomonas Putida, Escherichia Coli, Aspergillus Niger and Candida Albicans. Thiosemicarbazone and its cobalt (II) complexes have also been found antioxidant. 


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