Stability indicating RP-HPLC method for the estimation of lacosamide in bulk and pharmaceutical dosage form


ABSTRACT:

chemically described as N2 -acetyl-N-benzyl-D-homoserinamide used for the treatment of . It can also be prescribed off-label to treat conditions such as diabetic neuropathic pain. It enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyper excitable neuronal repetitive neuronal firing. analytical methods [2-10] have been reported for the estimation of , accurate and stability indicating reversed-phase HPLC method lacosamide in pharmaceutical dosage form as per ICH Figure 1: Chemical structure of lacosamide EXPERIMENTAL SECTION out on Waters HPLC system (2695 module) equipped with module) with auto sampler and running on Waters Empower software. The column used is Kromasil C Journal of Chemical and Pharmaceutical Research, 2013, 5(11):732-739 ISSN : 0975-7384 CODEN(USA) : JCPRC5 method for the estimation of lacosamide in and Ajaya Kumar Patnaik3 Vizianagaram, A.P, India ences, Berhampur, Orissa, India versity, Cuttack, Orissa, India.

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