Simultaneous estimation of gatifloxacin and flurbiprofen sodium in ophthalmic formulation by UV- specrophotometric method


ABSTRACT:

A UV- Spectrophotometric method has been developed for the determination of Gatifloxacin and Flurbiprofen Sodium in their pharmaceutical formulation. The wavelength method involved solving simultaneous equations based on measurement of absorbance at two maximum wavelengths 245 nm and 293 nm for Flurbiprofen Sodium and Gatifloxacin respectively. The method was validated for various parameter according to ICH guideline. The linear regression analysis data for the calibration plots showed good linear relationship in the concentration range of 6 - 18 µg/ml and 0.6 – 1.8 µg/ml and correlation.

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