Synthesis and anticonvulsant activity of 1-[(4, 5-d ihydro-5-phenyl-3- (phenylamino)pyrazol-1-yl)]ethanone derivatives


Abstract

In present study a series of chalcones of anilide and their corresponding product 1-[(4,5-dihydro-5-phenyl-3-(phenylamino)pyrazol-1-yl)]ethanone derivatives I-VI were synthesized and evaluated for their anticonvulsant activity againstelectric shock induced convulsion method in rat at a dose of 125 mg/kg and 250 mg/kg intra peritonially. The structures of compounds were confirmed by IR, H1NMR and Mass spectroscopy. The compounds of this series (III) and (V) were found to be most potent, which have shown higher percent of anti convulsant activity. Phenytoin was taken as reference drug. Their pharmacophoric groups are similar and the possible structure of suitable fused heterocyclic could be accepted to give anti convulsant activity

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