Synthesis, characterization and biological activity of metal complexes of 3-amino-5-methyl isoxazole Schiff base s


Abstract 

Metal chelates of biologically important Schiff bases namely 4-methyl-2{[(5'-methyl-3'-isoxazolyl)imino] methyl} phenol(MEMIIMP) and 5-methoxy-2--{[(5'-methyl-3'-isoxazolyl)imino] methyl} phenol(MMIIMP) with Cu(II), Ni(II), Co(II), Zn(II) and VO(IV) have been synthesized. The metal chelates have been characterized by elemental analysis molar conductivity data TG, DTA, spectral (IR, 1H-NMR, Mass, ESR and electronic) and magnetic moments. The dissociation constants of Schiff basesand stability constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes have been determined potentiometrically in aquo organic medium at 30±1oC and at 0.1 M KNO3ionic strength. Antimicrobial activities of Schiff bases and their complexes were screened against bacteria & fungi are discussed. 

For more info: http://www.jocpr.com/articles/synthesis-characterization-and-biological-activity-of-metal-complexes-of-3amino5methyl-isoxazole-schiff-bases.pdf

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