UV-spectrophotometric method development and valida tion for estimation of Galantamine Hydrobromide in tablet do sage form

Abstract 

Two innovative, new, simple and low cost UV-spectrophotometric and first order derivative methods were developed and validated for estimationof Galantamine Hydrobromide in bulk drug and tablet dosage form. Galantamine Hydrobromide was estimated at 289 nm in Distilled Water. In first order derivative, it showed amplitude at 284.8 nm and λminima = 290.4 nm with 286.4 nm as zero crossing point (ZCP). In both the methods linearity was found to be in the range of 20-100 μg/ml; for UV spectrophotometric method (y = 0.007x - 0.002, r² = 0.999) and for first order derivative spectrophotometric method (Y=0.0012 x+0.00045; r2=0.999), respectively. These methods were analyzed and valiated for various validation parameters according to USP guidelines

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